Research Article

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

Table 1

Effect of MT-1303 and FK506 on histological scores in the kidneys.

TreatmentHistological score ()
Mesangial expansionGlomerular sclerosisInterstitial infiltratesPerivascular infiltrates

Control
MT-1303 0.1 mg/kg
MT-1303 0.3 mg/kg
FK506 1 mg/kg

, Shirley-Williams test (, control group vs. MT-1303 groups), Wilcoxon test (control group vs. FK506 group).