Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes

<div>Introduction of <i>p</i>-nitrophenylalanine allows Th epitopes to activate human naïve CD4<sup>+</sup> T cells. (a) CFSE-labeled human naïve CD4<sup>+</sup> T cells were cocultured with autologous DCs pulsed by various NitraTh-based vaccines for 7 days and analyzed by FACS. One of representative experiments was shown. (b) The results of (a) were analyzed. 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Journal of Immunology Research

fig1

Figure 1

Figure 1: Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes 

Figure 1 | Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes 