| Study NO | Demographic information | Tumor site | Tumor size | TNM stage | Smoking | Alcohol | Pathological features | Treatment strategy | Follow-up (months) |
| Patient A | Male, 36 years, Asian | Tongue | Ulceration, diameter 2.0 cm | T2N1M0 | Yes | Yes | Well-moderately differentiated SCC, lymph node metastasis, 1.0 cm depth of invasion, invasion of striated muscles | Operation: extensive resection of tongue cancer and cervical lymph node dissection; radiotherapy but without chemotherapy | No recurrence, 25 months | Patient B | Male, 39 years, Asian | Tongue | Ulceration, diameter 1.3 cm | T1N1M0 | Yes | No | Well differentiated SCC, lymph node metastasis, 0.2 cm depth of invasion | Operation: extensive resection of tongue cancer and cervical lymph node dissection; without radiotherapy and chemotherapy | No recurrence, 24 months | Patient C | Female, 41 years, Asian | Tongue | Ulceration, diameter 1.3 cm | T2N1M0 | No | No | Well differentiated SCC, lymph node metastasis, 0.6 cm depth of invasion, invasion of striated muscles and nerves | Operation: extensive resection of tongue cancer and cervical lymph node dissection; without radiotherapy and chemotherapy | Death, 21 months | Patient D | Female, 29 years, Asian | Tongue | Ulceration, diameter 1.8 cm | T2N1M0 | No | No | Well differentiated SCC, lymph node metastasis, 1.0 cm depth of invasion | Operation: extensive resection of tongue cancer and cervical lymph node dissection; without radiotherapy and chemotherapy | No recurrence, 26 months |
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