Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration

Figure 2

Increased DC migration induces more effective therapeutic effects. After internalization of the antigen (Ag), DCs mature and migrate to naïve T cells in the draining lymph node (dLN) to present Ag. DCs with enhanced migratory ability moving to LNs more extensively increase the proliferation and differentiation. Conversely, DCs with low migratory ability produce less DC migration to the LN, making it difficult to promote T-cell proliferation.