Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry

Figure 1

CyTOF analysis of circulating immune cell subsets in the active PsA group and active PsV group: (a) t-SNE plots showed 41 cell clusters of circulating immune cells (left) and distinct immune landscape of two groups of patients (right), (b) heatmap of the median arcsine transformed marker intensity normalized to a 0–1 range of the 42 phenotyping panel markers across the 41 annotated clusters, and (c) clusters with significant differences between the PsA group and PsV group. Data are shown as box plots extending from the 25^th to 75^th percentiles and the whiskers from the minimum to the maximum point; the middle line represents the median. p values were calculated using two-sided unpaired t-test or Mann–Whitney U test according to data distribution ( = ,  = ,  = ,  = ). PsA, psoriatic arthritis; PsV, psoriasis vulgaris; NK, natural killer cell; Treg, regulatory T cell; T_N, naïve T cell; T_CM, central memory T cell; T_EM, effector memory T cell; T_FH, follicular helper T cell; and pDC, plasmacytoid dendritic cell.

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