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Immunology in Ocular Disorders: Novel Advances

Call for Papers

Ocular disorders involve a broad spectrum of hereditary and sporadic diseases with diverse genetic backgrounds, molecular pathologies, and clinical characteristics. Several progressive ocular diseases (e.g., age-related macular degeneration, glaucoma, and diabetic retinopathy) that affect considerable numbers of people and are untreatable in the majority of patients are becoming the primary causes of blindness worldwide. These pernicious fatal processes have spurred intensive studies on both the nature of ocular diseases and the molecular mechanisms that may modulate the ultimate course of these diseases. Basic and clinical research investigations indicate that the immune system might play a role in the pathogenesis of such disorders. Therefore, a thorough understanding of the pathophysiological background and immune-related mechanisms underlying these conditions is critically needed to further improve therapeutic outcomes in the clinic. Moreover, recent research conducted by many academic laboratories and pharmaceutical industries has offered novel technologies to study ocular disorders and the molecular mechanisms underlying their pathology in detail and has highlighted this field of research.

Accordingly, we invite investigators to contribute original research and review articles that will focus on efforts to understand and elucidate various aspects of the immunological mechanisms accompanying selected ocular disorders. Despite the complexity of the underlying pathology, the potential role of immunological factors might be underestimated in the course of ocular diseases. We are especially interested in articles that explore immunological aspects of particular mechanisms of ocular disorders, with specific insights into the recent advances in soluble immune mediators (e.g., cytokines, chemokines, and antibodies) that might orchestrate the complex cross-talk between ocular tissues and the immune system and the potential applications of these advances in the field of clinical ophthalmology. Potential topics include, but are not limited to:

  • Immune-related mechanisms involved in degenerative ocular diseases
  • The role of the complement system and inflammasomes in retinal degeneration
  • Inflammation in the pathogenesis of glaucoma and diabetic retinopathy
  • Recent proceedings in corneal immunopathology
  • Immunological aspects of different ocular disorders
  • Immunology and molecular biology of ocular inflammatory disorders

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/aiod/ according to the following timetable:

Manuscript DueFriday, 28 March 2014
First Round of ReviewsFriday, 20 June 2014
Publication DateFriday, 15 August 2014

Lead Guest Editor

  • Boguslaw Machalinski, Department of General Pathology, Pomeranian Medical University, Szczecin, Poland

Guest Editors

  • Kai Kaarniranta, Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
  • Juan E. Gallo, Department of Ophthalmology, Austral University Hospital and Faculty of Biomedical Sciences, Austral University, Buenos Aires, Argentina
  • Jacek Rolinski, Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland
  • Edward Wylęgała, II Ophthalmology Clinic, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Railway Hospital, Katowice, Poland