Clinical Outcomes of Transcatheter Aortic Valve Replacement in Nonagenarians: A Systematic Review and Meta-Analysis

Table 1

(a) Baseline characteristics of the included studies

First Author	Country	Year	Multicenter	Number of Patient		Mean Age (years)		Male (%)
				nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group
Yamamoto et al.	France	2012	No	26	110	91.6±1.9	82.3±7.0	19	50
Arsalan et al.	United States	2016	Yes	3773	20252	92.0 (90.0-93.0)	82.0 (76.0-86.0)	48.24	50.74
Ramkumar et al.	Australia	2016	No	23	81	90.6±2.6	81.1±4.6	52	44
Miura et al.	Japan	2017	No	25	87	91.6±1.7	82.5±6.0	20	37.9
Scholtz et al.	Germany	2017	No	82	912	91.8±1.4	84.8±2.6	19.5	58.8

(b) Baseline characteristics of patients in the included studies

First Author	Mean STS (%)		Logistic EuroSCORE		Left Ventricle EF (%)		Mean Gradient (mm Hg)
	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group
Yamamoto et al.	13.4±7.2	12.3±8.8	26.6±9.3	23.6±12.4	51.3±12.3	48.6±14.2	56.3±23.4	45.5±15.4
Arsalan et al.	9.22 (6.73-13.25)	6.34 (4.20-9.77)	NR	NR	58(48-65)	56(45-63)	NR	NR
Ramkumar et al.	5.7±2.2	3.6±1.8	5.5±5.4	4.0±3.3	53.7±17	59.1±11	44.7±14	49.6±16
Miura et al.	10.0(7.5-12.0)	6.0(3.0-7.0)	20.0(16.0-25.5)	14.0(11.0-22.0)	63.2±6.9	61.8±9.0	59.6±19.0	54.2±19.9
Scholtz et al.	8.5±4.8	6.3±4.5	27.7±14.8	23.1±14.4	54.6±9.5	52.5±11.4	47.1±17.3	45.1±16.8

(c) Medical history of patients in the included studies

First Author	Hypertension (%)		Diabetes Mellitus (%)		CAD (%)		Stroke (%)		NYHA III-IV (%)		COPD (%)
	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group	nonagenarian group	control group
Yamamoto et al.	73	76	23	25	NR	NR	NR	NR	65	64	19	30
Arsalan et al.	86.56	89.26	19.35	40.39	NR	NR	9.33	12.77	80.97	81.37	15.4	30.1
Ramkumar et al.	57	81	14	26	22	20	9	17	74	69	27	23
Miura et al.	72	71.3	4	26.4	20	44.8	4	15.1	72	63.2	12	17.2
Scholtz et al.	82.9	79.6	11	22.1	50.1	57	NR	NR	NR	NR	15.9	14.5

CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease.