Mechanism of Resistance to Dietary Cholesterol

Table 4

Microarray analysis identifying genes downregulated by dietary cholesterol.

Normal			Cholesterol			Fold diff	Gene
1185	2381	1598	219	232	203	−7.9**	Squalene epoxidase
588	783	426	148	84	143	−4.8**	ABCG8
574	373	195	51	144	62	−4.5	Hypo protein XP_580018
2353	3066	2285	735	783	503	−3.8*	Acetyl CoA Acetyltransferase2
10377	11676	10752	2690	3350	3329	−3.5**	Lanosterol 14α demethylase
3890	4874	3668	929	1280	1426	−3.4**	Delta 14 sterol reductase
1049	893	1196	186	216	542	−3.3**	Cytokine inducible SH2 protein
238	316	242	65	115	76	−3.1**	Nuc factor, erythroid derived 2
733	1023	760	233	232	345	−3.1**	Ephrin A5
1998	608	524	340	343	375	−3.0	Dual specificity phosphatase1
11250	14322	9729	3511	4636	4315	−2.8**	Sterol C4 methyl oxidase-like
6083	6326	4997	1961	2597	2103	−2.6**	7-Dehydrocholesterol reductase
2851	2771	2112	1027	879	1055	−2.6**	Solute carrier family 25 mem 30
14079	17666	16412	5555	6296	7154	−2.5**	HMG-CoA Synthase 1
14890	13208	12147	5146	5920	5178	−2.5**	Farnesyl diphosphate synthase
1857	2636	1792	882	1025	635	−2.5**	Lanosterol synthase
4946	5502	4267	1503	2456	1667	−2.6**	Farnesyl diphos transferase 1
1695	2518	1567	870	834	814	−2.3*	ABCG5
13476	13702	14018	6048	7357	5541	−2.2**	Fatty acid desaturase 1
10599	8161	6620	3050	4215	4797	−2.1*	Hemato expressed homeobox
444	591	470	225	288	205	−2.1**	Acetoacetyl CoA synthase
1269	1465	1136	604	749	548	−2.0**	Hypo protein XP_579849
10087	11135	8727	4223	5304	5287	−2.0**	HMGCR
2516	2177	2744	1138	1049	1509	−2.0**	Forkhead box A2
848	1080	873	538	444	432	−2.0**	Mevalonate kinase

* 𝑃<0.05; **𝑃<0.01. A 2-tailed distribution t-test, equal variance was used.