Mechanism of Resistance to Dietary Cholesterol

Table 5

RT-PCR analysis.

Gene	Normal	Cholesterol	Fold	𝑃 value
ABCG5	1.00 ± 0.07	0.67 ± 0.09	−1.49	0.018
ABCG8	1.02 ± 0.17	0.17 ± 0.03	−6.00	0.003
HMG-CoA synthase	1.03 ± 0.23	0.23 ± 0.01	−4.48	0.008
Squalene epoxidase	1.17 ± 0.26	0.14 ± 0.03	−8.29	0.002
Lanosterol 14α demeth	0.71 ± 0.28	0.16 ± 0.01	−4.53	0.027
Delta 14 sterol reductase	1.03 ± 0.31	0.19 ± 0.15	−5.33	0.013
Lanosterol synthase	1.12 ± 0.58	0.33 ± 0.14	−3.39	0.083
ACAT-2	1.00 ± 0.08	0.31 ± 0.07	−3.20	0.001
Sterol C4 Me Ox like	1.04 ± 0.31	0.39 ± 0.50	−2.65	0.128
7-Dehydrocholesterol red	1.01 ± 0.13	0.50 ± 0.06	−2.00	0.004
HMG-CoA reductase	1.02 ± 0.26	0.73 ± 0.28	−1.40	0.261
PPAR gamma	1.07 ± 0.40	1.02 ± 0.89	−1.04	0.944
PPAR alpha	1.01 ± 0.18	1.06 ± 0.44	+1.05	0.852
Lipin 2 (predicted)	1.03 ± 0.29	1.64 ± 0.42	+1.59	0.105
Chol 7α hydroxylase	1.17 ± 0.35	3.27 ± 0.97	+2.79	0.044
IGFBP1	1.02 ± 0.31	4.30 ± 1.90	+4.22	0.042

A 2-tailed distribution t-test, equal variance was used.