A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways

Figure 2

The SHP-mediated repression of target transcription factors occurs by at least three distinct transcriptional repression mechanism: (a) direct interference with the AF-2 coactivator domain of NRs (competition for coactivator binding, leading to the repression of NR-mediated transcriptional activity); (b) recruitment of corepressors, resulting in active repression; (c) direct interaction with the surface of NR or transcription factor, resulting in the blockade of DNA binding and the consequent inhibition of its transcriptional activity. See text for details. The dotted arrows and (-) symbols indicate inhibition. CoA: coactivator; CoR: corepressor; NR: nuclear receptor; SHP: small heterodimer factor; TF: transcription factor. Modified after [12, 15, 131].