Research Article

Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties

Figure 2

PON2 or PON3 overexpression diminishes NF-κB activation induced by P. aeruginosa signaling molecule PCN. A549 cells transiently overexpressing HA or PON2-HA (a) and GFP or PON3-GFP (b) were stimulated with PCN (100 μM, 4 h) and analyzed for NF-κB activation. Symbols represent ± S.E.M. 𝑛 = 6 - 9 ; 𝑃 < 0 . 0 0 1 .
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(a)
352857.fig.002b
(b)