Research Article

Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties

Figure 3

PCN induces IL-8 secretion, which can be lowered by PON2 or PON3 overexpression. (a) Naïve, PON2-GFP or PON3-GFP overexpressing EA.hy 926 cells were treated with PCN (10 μM, 16 h). Cell supernatants were analyzed for the secretion of the listed cytokines and chemokines by ELISA. (b) Quantitative evaluation of results from panel (a) Fold induction of IL-8 release was calculated between untreated and PCN-treated samples.
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(a)
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(b)