Molecular Characterization of Lipopolysaccharide Binding to Human α-1-Acid Glycoprotein

Table 1

The structures of the core oligosaccharide and 𝑂-antigen polysaccharides of the LPS samples used in this study. The general structure of the Salmonella LPS is shown in the first row. The stages at which the biosynthetic enzyme defects disrupt biosynthesis resulting in the production of the truncated “rough” LPS chemotypes R_a→R_e are indicated by the segmented arrows.

General structure of the Salmonella LPS
O-antigen structures
E. coli serotype O111:B4 [24]
Neutral
E. coli serotype O127:B8 [24]
Neutral
E. coli serotype O55:B5 [24]
Neutral
Klebsiella pneumoniae serotype O2a,c [25, 26]
Neutral
Pseudomonas aeruginosa serotype O10 [27–29]
Acidic
Salmonella typhimurium  O-antigen 4,5,12 [30, 31]
Neutral
LPS core region structures
E. coli R2 core Serotype O127:B8 [7, 30, 31]
Acidic
E. coli R3 core Serotype O111:B4 and O55:B5 [7, 30, 31]
Acidic
E. coli EH100 (Rough, Ra) [7, 30, 31]
Acidic
E. coli F583 (Rough, Rd) [7, 30–32]
Acidic
Klebsiella pneumoniae serotype O2 [7, 25, 26]
Acidic
Pseudomonas aeruginosa serotype O10 [27–29]
Acidic
Salmonella typhimurium (smooth) [30, 31]
Acidic
Salmonella typhimurium TV119 (Rough, Ra) [30, 31]
Acidic
Salmonella typhimurium SL1181 (Rough, Re) [30, 31]
Acidic
Serratia marcescens [33, 34]
Acidic