Journal of Lipids

Research Article

Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease

Table 1

Characteristics of the 51 SNPs studied in the PON gene cluster.


SNP	Gene	Function^a	Minor allele^b	Major allele	MAF^c

rs854549	PON1	3′-downstream	A	C	0.337
rs3735590	PON1	3′-UTR	A	G	0.060
rs3917577	PON1	3′-UTR	G	A	0.089
rs854552	PON1	3′-UTR	G	A	0.265
rs3917551	PON1	Intronic	A	G	0.051
rs3917550	PON1	Intronic	A	G	0.137
rs2269829	PON1	Intronic	G	A	0.278
rs3917542	PON1	Intronic	A	G	0.227
rs3917538	PON1	Intronic	A	G	0.236
rs2299257	PON1	Intronic	C	A	0.391
rs854560	PON1	Coding	T	A	0.360
rs3917498	PON1	Intronic	A	C	0.345
rs28699500	PON1	Intronic	G	A	0.289
rs854561	PON1	Intronic	A	G	0.357
rs854565	PON1	Intronic	A	G	0.294
rs2272365	PON1	Intronic	C	A	0.154
rs854567	PON1	Intronic	A	G	0.185
rs3917490	PON1	Intronic	A	G	0.490
rs2299261	PON1	Intronic	G	A	0.354
rs854568	PON1	Intronic	G	A	0.219
rs2299262	PON1	Intronic	A	G	0.399
rs854569	PON1	Intronic	A	C	0.216
rs2237583	PON1	Intronic	A	G	0.284
rs3917486	PON1	Intronic	A	G	0.054
rs3917481	PON1	Intronic	A	G	0.015
rs2237584	PON1	Intronic	A	G	0.058
rs3917478	PON1	Intronic	G	A	0.118
rs3917476	PON1	Intronic	A	C	0.031
rs854571	PON1	5′-upstream	A	G	0.289
rs13236941	PON1	5′-upstream	A	G	0.164
rs13228784	PON1	Intronic	G	A	0.255
rs17883513	PON1	Intronic	G	A	0.032
rs17886762	PON1	Intronic	A	G	0.072
rs17883952	PON1	Intronic	A	G	0.052
rs17884000	PON3	Intronic	G	A	0.202
rs9640632	PON3	3′-UTR	G	A	0.456
rs468	PON3	Intronic	G	A	0.066
rs11768074	PON3	Intronic	A	G	0.157
rs10487132	PON3	Intronic	G	A	0.390
rs740264	PON3	Intronic	C	A	0.254
rs17884563	Intergenic	Intergenic	T	A	0.109
rs17880030	Intergenic	Intergenic	A	G	0.199
rs17881071	Intergenic	Intergenic	A	G	0.198
rs2375005	PON2	Intronic	T	A	0.462
rs12026	PON2	Coding	C	G	0.240
rs2299264	PON2	Intronic	A	G	0.241
rs7803148	PON2	Intronic	A	G	0.405
rs2158806	PON2	Intronic	C	A	0.237
rs2286233	PON2	Intronic	A	T	0.131
rs10259688	PON2	Intronic	G	A	0.179
rs730365	PON2	Intronic	A	G	0.132

Abbreviations: UTR = untranslated region, MAF = minor allele frequency, intergenic = located between two gene regions.
^a SNP functional annotation from SNP-Nexus.
^b Major and minor allele annotation from the Illumina HumanCVD Bead Chip.
^c Minor allele frequencies calculated from the CLEAR study cohort.