Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease

Table 5

Comparison of SNPs found significant in prior Carlson et al.^a study with current, non-overlapping sample.

SNP	Seattle SNP annotation	Carlson coefficient (±SE)	Carlson t-Statistic ^b	Carlson P ^c	Current coefficient (±SE)^d	Current t-Statistic ^b	Current P ^c
rs854566^e	PON16842	−10.6(±4.3)	−2.480	0.014	−20.4(±4.68)	−4.353	1.64×10−5
rs3917510	PON112471	16.6(±6.9)	2.424	0.016	14.3(±6.48)	2.208	0.028
rs2269829	PON119470	−16.5(±10.8)	−1.520	0.129	13.6(±21.82)	0.625	0.533
rs3917564	PON123887	−39.0(±18.1)	−2.153	0.032	15.0(±26.67)	0.564	0.573
rs854549	PON129021	9.2(±4.5)	2.051	0.041	−1.3(±4.90)	−0.260	0.795
rs854572	PON1895	13.0(±4.9)	2.677	0.008	−0.28(±4.97)	−0.056	0.955

SE = standard error.
^aCarlson et al. study 𝑛=500 European male subjects [27].
^bt-Statistics and 𝑃-values were calculated from the coefficients from each subgroup (Carlson 𝑛=500, current study 𝑛=523) and standard errors within the best-fit multivariate model by the glm function in R.
^cBoth Carlson and current study utilized a linear regression model adjusting for age, current smoking status, and the four functional PON1 SNPs.
^dCurrent study subset of 523 European male subjects not considered by Carlson et al.
^eRepresented by proxy SNP, rs854457, with LD 𝑟²=0.93 in the current study.