Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose of Trans-10, cis-12-Conjugated Linoleic Acid

Table 1

Summary of the changes in liver mass, liver TG, and adipose tissue mass observed in previous mouse studies feeding different levels of trans-10, cis-12-CLA compared with feeding linoleic acid (LA) or oleic acid (as canola oil).

Reference	Dose	Duration	trans-10, cis-12 CLA response^2
			Liver mass	Liver TG/fat	Adipose mass
Clément et al. (2002) [5]	0.4%	4 weeks	3.1 fold ↑	N.A^1	80% ↓
Halade et al. (2009) [53]	0.5%	0.5 year	50% ↑	N.A	73% ↓
Degrace et al. (2003) [12]	10 g	4 weeks	60% ↑	655% ↑	83% ↓
Kelley et al. (2004) [7]	0.5%	8 weeks	N.A	5 fold↑	N.A
House et al. (2005) [10]	1%	2 weeks	33% ↑	61% ↑	58% ↓
Warren et al. (2003) [54]	0.5%	8 weeks	98% ↑	427% ↑	59% ↓
Degrace et al. (2004) [13]	1%	4 weeks	80% ↑	646% ↑	85% ↓

¹Not available.
²Percentage = [Wt of CLA-fed Mice − Wt of LA or canola oil-fed Mice]/[Wt of LA or CO-fed Mice]×100.