Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose of Trans-10, cis-12-Conjugated Linoleic Acid

Table 3

Long-chain fatty acid concentrations in liver from mice fed control or the control supplemented with trans-10, cis-12-CLA (CLA). There were few significant interactions of treatment × time. Therefore, the results are presented according to main effects (treatment and time).

Item	Treatment		Time		SEM
	Control	CLA	Week 2	Week 6
Total fatty acids, 𝜇g/mg dry liver	42.5^b	60.3^a	41.0^b	61.7^a	4.5
16: 0	22.5	24.1	28.6^a	17.9^b	1.2
18: 0^3	19.6^a	14.0^b	20.9^a	12.7^b	1.1
cis-9-18: 1	20.1^b	24.4^a	24.4^a	20.2^b	1.3
trans-10-18: 1	0.02^b	0.05^a	0.05^a	0.02^b	0.01
trans-11-18: 1	0.07	0.06	0.07	0.05	0.01
cis-9,cis-12-18: 2	18.0	19.2	13.5^b	23.7^a	1.4
cis-9,cis-12,cis-15-18: 3	0.60	0.56	0.68^a	0.48^b	0.07
CLA isomers
cis-9,trans-11-18: 2	0.01	0.03	0.03	0.02	0.01
trans-10,cis-12-18: 2^1	<0.00^b	0.30^a	0.11^b	0.19^a	0.02
Total^1	0.13^b	0.46^a	0.29	0.30	0.02
20: 4n-6	8.3	6.1	3.0^b	11.4^a	0.9
22: 6n-3	4.1	3.4	1.0^b	6.5^a	0.6
Total 20-carbon	14.2	11.4	5.3^b	20.2^a	1.5

^a,bMeans within each main effect (treatment and time) with different superscripts differ (𝑃≤0.05).
SEM: the largest standard error of the mean is shown.
¹Significant treatment × time.