Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose of Trans-10, cis-12-Conjugated Linoleic Acid

Table 4

Hepatic expression of genes related to LCFA uptake, lipogenesis, TG synthesis, lipoprotein synthesis, and transcription regulation in mice fed control or the control supplemented with trans-10, cis-12-CLA. There were no significant interactions of treatment × time. Therefore, the results are presented according to main effects (treatment and time).

Gene	Treatment		Time		SEM
	Control	CLA	Week 2	Week 6
Fatty acid uptake
Cd36	−1.47^a	1.11^b	−0.01	−0.35	0.55
Slc27a2	−0.23	−0.04	−0.07	−0.20	0.18
De novo synthesis and desaturation
Acaca	0.22^a	0.72^b	0.42	0.51	0.11
Scd	−0.92^a	0.05^b	−0.50	−0.37	0.19
TG and lipid droplet synthesis
Dgat1	−0.02	0.30	0.23	0.05	0.17
Dgat2	0.03	0.25	0.26	0.02	0.15
Gpam	−0.31^a	0.44^b	0.13	0.004	0.17
Pck1	−1.74^a	−0.29^b	−0.80	−1.24	0.62
Plin2	−0.43^a	0.40^b	−0.01	−0.02	0.18
Transcription regulation
Chrebp	−0.22	−0.17	−0.19	−0.19	0.08
Srebf1	−0.22^a	0.14^b	0.04	−0.11	0.11
VLDL synthesis
Apob	−0.33	−0.05	−0.09	−0.29	0.19
Cideb	−1.13^a	−0.04^b	−0.35	−0.81	0.50
Mttp	−0.37^a	0.14^b	0.002	−0.22	0.17
Carbohydrate Metabolism
Gck	−0.45	−0.49	−0.31	−0.63	0.28
Pc	−0.31	−0.08	−0.08	−0.32	0.28
Slc2a1	−0.07	0.21	0.18	−0.04	0.14
Lipolysis
Lipc	−0.95	−0.20	−0.15	−1.00	0.54
Pnpla2	−0.04	0.14	0.24	−0.13	0.24

^a,bMeans within each main effect (treatment and time) with different superscripts differ (𝑃≤0.05).
SEM: the largest standard error of the mean is shown.