Lipid Peroxidation and Paraoxonase-1 Activity in Celiac Disease

Table 2

PON1 activities, markers of lipid oxidative stress (levels of lipid hydroperoxides and lag time of conjugated dienes) and total antioxidant capacity (TAC) in serum of healthy subjects, celiac patients at diagnosis (CD patients), and celiac patients treated with a gluten-free diet (GFD patients). Data are given as median (range) for paraoxonase activities and means ± S.D. for other biochemical parameters.

	Healthy subjects (𝑛=25)	Celiac patients (𝑛=27)
		CD patients (𝑛=11)	GFD patients (𝑛=16)
PON1 Activities
Paraoxonase (U/mL)	306 (165.6–608.1)	101.5 (61.2–141.6)*	184.9 (75.3–347.8)^*#
Lactonase (U/mL)	68 (32–184)	34 (19.7–68.5)*	54.7 (16.5–101.6)^*#
Arylesterase (U/mL)	228 (90–612)	73.2 (41.2–109.7)*	105.5 (68.2–148.7)^*#
Lipid hydroperoxides (μmol/L)	2.02±0.76	5.31±1.62 *	4.14±1.50^*#
Lag time (min)	66.4±16.2	39.4±7.2 *	46.7±12.8^*#
TAC (μM TE)	12048±2678	8796±976 *	9977±1021^*#

^*𝑃<0.001 versus controls; ^#𝑃<0.05 versus CD patients.