Sphingolipid Metabolic Pathway: An Overview of Major Roles Played in Human Diseases

Figure 5

Status of different compartments in Alzheimer’s disease. In Alzheimer’s disease condition, there is an upregulation of genes involved in the de novo ceramide synthesis (⚫) and downregulation of CERT (x). This contributes towards ER stress. CERK gene which generates C1P a progrowth molecule is downregulated (x). Down regulation of ceramidase might lead to accumulation of ceramide which is a proapoptotic molecule. Overall this scenario would result in ER stress and proapoptotic phenotype.