5-Lipoxygenase-Activating Protein as a Modulator of Olanzapine-Induced Lipid Accumulation in Adipocyte
Figure 2
Effect of olanzapine on intracellular lipid content measured by a quantitative Oil Red O assay. 3T3-L1 cells were differentiated into adipocytes in the presence and absence of 50 μM olanzapine. Samples (3 culture dishes per treatment and time point) were collected daily starting 24 hours after the initiation of the differentiation protocol. Results (mean ± SEM) are expressed as optical density (O.D.) readings at 520 nm. At each time point, the values of olanzapine-treated cultures differed significantly from the values measured in corresponding vehicle-treated cultures (*; -test).
