Research Article

Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR Signaling and Inflammation in Murine Mammary Tissue

Table 4

Fold change in expression among the most up- and downregulated DEG in mammary tissue of lactating mice fed trans-10, cis-12-CLA.

SymbolNameCLA versus controlP value

Upregulated genes

Defb Defensin, beta14.60.004
Hprt1 Hypoxanthine phosphoribosyl transferase 13.70.065
Orm1 Orosomucoid 13.70.001
Sphk1 Sphingosine kinase3.60.011
Kif26b Kinesin family member 26b3.60.002
Cp Ceruloplasmin (ferroxidase)2.90.003
Clca1 Chloride channel calcium activated 12.70.002
Saa2 Serum amyloid A22.60.026

Downregulated genes

Mup4 Major urinary protein 4−8.40.001
Mup2 Major urinary protein 2−4.60.001
Ca3 Carbonic anhydrase III−3.70.006
Adipoq Adiponectin−3.60.001
Tbp TATA box binding protein−3.20.011
Scd Stearoyl-CoA desaturase−3.10.001
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast)−2.70.001
Smpd3 Sphingomyelin phosphodiesterase 3−2.40.001
Cfd Complement factor D (adipsin)−2.40.001
Tubg2 Tubulin, gamma 2−2.20.001