Research Article
Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality
Table 1
Main differences between ApoE2 and ApoE4 [
10ā
13].
| ā | ApoE2 | ApoE4 |
| Isoform difference | Cys-112 Cys-158 | Arg-112 Arg-158 |
| Structure difference | Cys-158 disrupts the salt bridge | Domain interaction (formation of a salt bridge between Arg-61and Glu-255) |
| Protein stability | High | Very low |
| Binding preferences | Preferentially binds to small phospholipid-rich HDL Severely defective in LDL receptor binding activity (<2% binding activity compared with ApoE3) | Binds preferentially to large, triglyceride-rich VLDL Binds avidly to LDL receptors |
| Serum lipid association | Tends to be associated with increased levels of ApoE and triglyceride and decreased levels of ApoB and cholesterol | Tends to be associated with decreased ApoE but increased ApoB and cholesterol levels |
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Arg: arginine; Cys: cysteine; HDL: high-density lipoprotein; LDL: low-density lipoprotein; VLDL: very-low-density lipoprotein.
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