Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality
Table 2
Subjects’ characteristics according to the apolipoprotein E genotype.
ApoE 2/4 (A)
ApoE 2/2 (B)
ApoE 2/3 (C)
ApoE 3/3 (D)
ApoE 3/4 (E)
ApoE 4/4 (F)
value
Men/women
51/53
48/46
326/330
660/625
247/239
24/31
NS
Age (years)
48.8 ± 12.7
50.8 ± 13.07
50.3 ± 11.2
48.8 ± 12.1
48.8 ± 11.9
46.2 ± 11.3
NS
Waist circumference (cm)
88.2 ± 13.2
90.7 ± 12.3
90.5 ± 13.3
89.8 ± 13.9
88.5 ± 13.1
86.6 ± 12.6
0.056
BMI (kg/m2)
26.6 ± 4.3
27.3 ± 4.3
26.9 ± 4.6
26.6 ± 4.5
26.5 ± 4.4
25.8 ± 4.3
0.082
Smoking habits1 (%)
66.3
61.7
68.4
65.4
67.3
58.2
NS
Type 2 diabetes1 (%)
10.6
11.7
14.5
14.7
14.4
9.1
NS
Hypertension1 (%)
42.3
38.3
39.6
37.1
41.2
30.9
NS
CAD (%)
29.8
28.7
27.9
28.4
24.5
27.3
NS
Triglycerides (mmol/L)
2.06 ± 1.95
1.88 ± 2.02
1.81 ± 2.18
2.20 ± 3.46
<0.001
Total cholesterol (mmol/L)†
5.52 ± 1.34
6.50 ± 3.16
5.37 ± 1.35
5.41 ± 1.05
5.64 ± 1.18
6.02 ± 1.11
<0.001
LDL-cholesterol (mmol/L)†
3.17 ± 0.89
2.66 ± 1.08
2.96 ± 0.90
3.27 ± 0.83
3.37 ± 0.82
3.40 ± 0.85
<0.001
HDL-cholesterol (mmol/L)
1.17 ± 0.44
1.13 ± 0.55
1.21 ± 0.44
1.22 ± 0.41
1.20 ± 0.42
1.14 ± 0.42
NS
Total ApoB (g/L)
1.05 ± 0.24
1.00 ± 0.26
1.06 ± 0.24
1.12 ± 0.25
1.20 ± 0.27
<0.001
Data are mean ± S.D. Note: ApoB: apolipoprotein B-100 measured on delipidated plasma; BMI: body mass index; CAD: coronary artery disease; HDL: high-density lipoprotein; LDL: low-density lipoprotein. 1Proportion (%) of individuals who ever smoked (smoking habits), are diabetic (type 2 diabetes), and are hypertensive. Among a subsample of 1,915 subjects. Significantly different () as compared to ; to E2/2; to E2/3; to E3/3. value obtained after log10 transformation of the data; geometric means are shown. †Kruskal-Wallis tests followed by Mann-Whitney U tests; geometric means are shown. NS = .
