Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]₄

Table 1

Thermodynamic parameters for the interaction of compound 1 and netropsin with [d(TGGGGT)]₄ determined by ITC at 25^∘C and pH 7.0.

Ligand	𝑛	𝐾𝑏(× 10^6 M^-1)	Δ𝑏𝐻^∘ (kJ mol^-1)	𝑇Δ𝑏𝑆^∘ (kJ mol^-1)	Δ𝑏𝐺^∘ (kJ mol^-1)
Compound 1	2.0 ± 0.1	1.9 ± 0.2	−11.0 ± 2.0	25 ± 2	−36 ± 2
Netropsin	2.0 ± 0.1	1.2 ± 0.1	−10.6 ± 1.0	23 ± 2	−34 ± 2