Formation, Repair, and Genotoxic Properties of Bulky DNA Adducts Formed from Tobacco-Specific Nitrosamines
Table 2
Comparative DNA adduct levels in lung and liver of F344 rats treated with 10 ppm NNK in the drinking water and sacrificed at various intervals [57, 58].
Adduct Levels fmol/mg DNA ()
Lung
Week
1
2
5
10
16
20
-mG
-pobdG
7-pobG
-pobdT
-pobC
Liver
Week
1
2
5
10
16
20
-mG
-pobdG
n.d.
n.d.
n.d.
n.d.
n.d.
n.d.
7-pobG
-pobdT
-pobC
n.d., not detected. Significantly different from -mG, .