Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls

Table 1

Means of DNA adducts ± standard error (SE) for different variables considered in the study plus the parameter estimates of the multivariate regression model.

	𝑁^a	Means^b±S.E.	Odds Ratio	C.I.	𝑃-value
Gender
Womanc	31	1.2±0.3	1
Male	73	1.3±0.2	0.65	0.19–2.16	.480
Age (years)
Per unit	104	1.3±0.2	1.02	0.97–1.06	.516
Smoking habit
Nonsmokerc	21	0.8±0.4	1
Former smoker	44	1.0±0.3	1.60	0.39–6.58	.517
Smoker <40 years	11	1.5±0.7	2.38	0.41–13.90	.336
Smoker ≥40 years	27	2.0±0.5	5.28	1.00–27.72	.049
Status
Controlsc	40	1.0±0.3	1
Benign lung disease	30	1.3±0.4	0.93	0.28–3.03	.898
Lung cancer	34	1.5±0.4	1.17	0.39–3.47	.783
XRCC1 Arg194Trp
Arg/Argc	87	1.1±0.2	1
Arg/Trp	11	2.6±1.1	4.08	0.77–21.48	.098
XRCC1 Arg399Gln
Arg/Argc	37	0.9±0.2	1
Arg/Gln	47	1.4±0.3	0.93	0.36–2.39	.882
Gln/Gln	12	1.8±1.0	1.32	0.34–5.18	.689
XRCC3 Thr241Met
Thr/Thrc	40	1.5±0.4	1
Thr/Met	41	1.2±0.3	0.38	0.15–0.97	.043
Met/Met	19	0.7±0.4	0.17	0.05–0.61	.006
Number of risk alleles
0-1c	25	0.8±0.4	1
2	31	1.0±0.3	0.92	0.31–2.69	.877
3-4	38	2.0±0.5	4.1	1.28–13.09	.009

aSome figures do not add up to the total because of missing values.
bLevels per 10⁸ normal nucleotides.
cReference level.