Research Article
“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles
Table 1
Competitive FRET-melting results of the 8 ligands selected after the second selection step.
| | in -conditions | in -conditions |
| | () | | () | |
| | no competitior | +3M ds26 | +10M ds26 | 10M ds26 | no competitior | +3M ds26 | +10M ds26 | 10M ds26 |
| 2,9- | 13.7 | 12.9 | 8.6 | 0.62 | 16.8 | 10.6 | 12.0 | 0.71 | 2,7-/2,7- | 19.9 | 16.8 | 13.5 | 0.68 | 20.1 | 17.6 | 16.1 | 0.79 | -1 | 31.9 | 24.3 | 22.9 | 0.71 | 29.7 | 23.9 | 21.5 | 0.72 | -2 | 33.2 | 11.8 | 12.0 | 0.36 | 25.9 | 16.5 | 12.6 | 0.48 | -1 | 31.8 | 18.8 | 16.1 | 0.50 | 25.8 | 19.1 | 17.2 | 0.66 | -2 | 18.2 | 10.7 | 9.3 | 0.51 | 13.6 | 12.7 | 11.5 | 0.84 | 2,7- | 23.4 | 9.5 | 11.6 | 0.49 | 22.8 | 16.9 | 13.1 | 0.57 | - | 13.0 | 9.7 | 13.1 | 1.01 | 14.9 | 14.7 | 14.7 | 0.98 |
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