Guanosine Quadruplexes in Solution: A Small-Angle X-Ray Scattering Analysis of Temperature Effects on Self-Assembling of Deoxyguanosine Monophosphate
Figure 1
Representation of the aggregates formed by d(pG) in water (yellow and green beads represent the sugar-phosphate residue and the monovalent cation, resp.). (A) guanosine molecule; (B) and (B') arrangement of four guanosine residues in a G-quartet (top and lateral views); , , and have the right size to occupy the tetramer inner cavity; (C) lateral view of the G-octamer, formed by two stacked quartets; the cation is located between the two quartets; (D) lateral view of the G-quadruplex, formed by stacking of discrete cation-bound quartets.
