Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens

<table>TFO and target DNA sequences.  TFOs composed of either DNA or <svg height="12.7625" id="M20" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 12.2875 12.7625" width="12.2875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.7625)">
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<text transform="matrix(1,0,0,-1,-71.95,61.84)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
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</svg>-<i>O</i>-methyl RNA are depicted. P represents HMT conjugated to the TFO by either a 2- or 6-carbon linker.</table>

Journal of Nucleic Acids

fig1

Figure 1

Figure 1: Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens 