Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens

Table 1

Binding and photoreactive efficiencies for TFOs conjugated to HMT.

TFO	𝐾𝑑		Photoefficiency
	Nondenaturing gel (nM)	Denaturing gel (nM)	𝑘1 (J/cm^2)^-1	𝑘2 (J/cm^2)^-1
TFO DNA-C2	63 ± 5	7.08 ± 2.6	19 ± 0.5	0.55 ± 0.04
TFO RNA-C2	75 ± 18	—	0	0
TFO RNA-C6	36 ± 4	10.96 ± 2.6	24 ± 4	1.6 ± 0.05