|
| Glycosylases | Organisms | Genes | Substrate |
|
| (1) Uracil DNA glycosylase | E. coli | Ung | uracil from ss- and ds-DNA |
| Dug/mug | U from U : G, ethenocytosine, hypoxanthine and 5-hydroxycytosine |
| Dut | ? |
| S. cerevisiae | UNG | Uracil |
| Human | UNG1/UNG2 | uracil from ss- and ds-DNA |
| SMUG1 | uracil from ss-DNA, hydroxymethyluracil, formyluracil |
|
| (2) 3-methyl adenine DNA glycosylase | E. coli | tag | 3-methyladenine |
| alkA | 3-methyladenine, 7-methylguanine, 2-methylcytosine, 5-formyluracil |
| S. cerevisiae | MAG1 | 3-methyladenine, 7-methylguanine |
| Human | MPG
Aag | 3-methyladenine hypoxanthine |
|
| (3) UV-endonuclease | T4 | den V | cis-syn-cyclobutane-type pyrimidine dimer |
| E. coli | ? | ? |
| Bacillus subtilis | UVDE | Pyrimidine dimers |
| S. cerevisiae | ? | ? |
| S. pombe | UVDE | Pyrimidine dimers |
| Human | ? | |
|
| (4) Endonuclease III/thymine glycol DNA glycosylase | E. coli | Nth | 5-hydroxycytosine, thymine glycol, urea |
| S. cerevisiae | NTG1 | oxidative DNA damage, thymine glycol and formamido-pyrimidines, oxidized pyrimidines, 2 formamido-pyrimidine-G, Me7- formamido-pyrimidine-G |
| NTG2 | oxidative DNA damage, Thymine glycol and formamido-pyrimidines residues, 5-hydroxycytosine, oxidized pyrimidines, Me7-fapy-G |
| Human | NTH1 | oxidized guanine lesions |
|
| (5) Endonuclease VIII | E. coli | nei | Thymine, thymine glycol, urea, 5-hydroxycytosine, dihydrothymine, and b-ureidoisobutyric acid |
| S. cerevisiae | ? | ? |
| Human | NEIL1 | 5-hydroxyuracil, 5-hydroxycytosine, 5,6-dihydrouracil, thymine glycol, formamido-pyrimidines (FapyA/G) |
| NEIL2 | 5-hydroxyuracil and 5-hydroxycytosine |
| NEIL3 | ? |
|
| (6) fapy/8-oxoguanine DNA glycosylase | E. coli | fpg/mutM | 2,6-diamino-5-formamidopyrimidine 8-oxo-7,8-dihydroguanine, 5-hydroxycytosine |
| S. cerevisiae | OGG1 | 2,6-diamino-5-formamidopyrimidine 8-oxoG, 2 formamidopyrimidine-G, Me7-formamidopyrimidine-G |
| Human | hOGG1 | 8-hydroxyguanine, Me7-formamidopyrimidine-G |
|
| (7) A-G-mismatch DNA glycolsylase | E. coli | mut Y | Adenine/C |
| S. pombe | spMYH | 2-aminopurine/G and A/2-aminopurine, Adenine/C |
| Human | MYH | Adenine from G : A, 8-oxoG : A, 2-hydroxyadenine |
|
| (8) G-T-mismatch DNA glycosylase | E. coli | ? | ? |
| M. thermoautrophicum | Mig-Mth | Thymine residues from T-G mismatches |
| S. pombe | thp1 | Uracil from G : U |
| Human | MBD4 (≈MED1) | Thymine from T : G |
| TDG | Recognizes a G : T mispair in a CpG sequence |
|
| (9) Formyluracil DNA glycosylase | E. coli | mug | Formyluracil mispaired with A & G |
| mutM | ? |
| mutS | Formyluracil mispaired with G |
| S. cerevisiae | ? | ? |
| Human | MBD4 | Formyluracil mispaired with G |
| hNTH1 | ? |
|
| (10) Hydroxymethyl uracil DNA glycosylase | E. coli | ? | ? |
| S. cerevisiae | ? | ? |
| Human | ? | 5-hydroxymethyluracil mispaired with G |
|
