Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Figure 3
(a) The thermal melting profile of poly(dT)poly(dA)xpoly(dT) triplex (-•-) and its complex with berberine at alkaloid/DNA ratio of 0.1 (-O-) and 0.3 (-▲-). (b) Circular dichroic spectrum () of the same triplex (48.8 M) with increasing concentrations up to (31.05 M) of berberine (). Reprinted in part from Das et al. [48] with permission from 2003 Adenine Press.
