Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Figure 5
(a) Absorption spectrum (1) of coralyne (7.09 M) with increasing concentrations up to 81.73 M (10) and 96.28 M (11) of calf thymus DNA. (b) The ITC profiles for the titration of calf thymus DNA (65 M) to coralyne (15 M) at 20°C. Each heat burst curve in the upper panel is the result of a 5 L injection of DNA into coralyne. The lower panel represents the corresponding normalized heat signals versus molar ratio. The data points reflect the experimental injection and the solid line represents the best fit of the data. Reprinted from the Ph.D. Thesis of Bhadra, [28].
