Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Figure 7
(a) Absorption spectrum (1) of sanguinarine (4.9 M) with increasing concentrations up to 54.8 M (10) of calf thymus DNA. Reprinted from the PhD Thesis of A. Das [71]. (b) The ITC profiles for the binding of sanguinarine (100 M) to Calf thymus DNA (15 M). The lower panel represents the corresponding normalized heat signals versus molar ratio. The data points reflect the experimental injection and the solid line represents the best fit of the data. Reprinted from the Ph.D. Thesis of Hossain [72].
