Review Article
Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Table 3
Thermodynamic parameters for the interaction of various alkaloids with calf thymus DNA complexation obtained from isothermal titration calorimetric studiesa.
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aAverage of four determinations, and ° values were determined from fits of the ITC profiles to Origin 7.0. The values of ° and ° were determined using the equations and . respectively. The ITC profile was fit to a model of single binding sites, where denotes the binding site size. |