Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Figure 8

DNA-PKcs kinase domain. The figure shows a cartoon of the overall structure of DNA-PKcs depicting the position of the kinase domain. The colour coding is as shown in Figure 6. The modelling of DNA-PKcs catalytic domain was based on the crystal structure of one of its family members, the PI(3)K𝛾 kinase (PDB code: 1E8X). Also shown is a closeup of DNA-PKcs catalytic domain. Helices of DNA-PKcs labelled (a) and (b) could be occupied by helices from the N-lobe of PI(3)K𝛾. The N-lobe helices displayed in light blue were omitted from the final structure of DNA-PKcs due to unclear electron density in this region.