Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

Figure 2

Structures of tobacco carcinogens, metabolites, and bulky dG adducts. These are only the partial list of DNA reactive carcinogens in cigarette smoke. The dG adducts listed are representatives of the adducts formed by the corresponding metabolites. Note that the stereochemistry of BPDE-DNA adducts is complex (see text). Acrolein can form two propano dG isomers, γ-HO-PdG (major), and α-HO-PdG (minor). CAA forms angular N²,3-εG, an isomer for 1, N²-εG.