Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

Figure 7

Summary of specificity of repair of tobacco carcinogen-induced bulky DNA adducts by the major DNA repair pathways. Some of the nonbulky DNA lesions and their repair mechanisms are also presented. For example, DSBs caused by cigarette smoke are repaired by nonhomologous end joining (NHEJ) and homologous recombination (HR). Note that overlapping substrate specificity is common.