Role of Topoisomerase II in DNA Damage Response following IR and Etoposide
Figure 2
H2AX foci formed in response to increasing doses of etoposide. WT and TOP2 MEFs were exposed to 0.1, 1, 10, and 100 M etoposide for 2 hours and then assayed for H2AX foci. (a) Histograms of foci number SEM at each dose counted. 100 M was not counted as foci were not distinct at this dose. Data derived from one experiment. (b) Representative images of H2AX foci (red) in nuclei stained with DAPI (blue) in WT and TOP2 MEFs.
