Structural Properties of G,T-Parallel Duplexes

Table 6

Free energy difference (in kcal/mol) in different folding processes associated to A→𝐴^𝑁 mutation. A negative sign means that the presence of 8-aminoadenine stabilizes the folded form (right species in column 2).

Mutation	Folding process	ΔΔGstab(kcal/mol)
	Single strand → ps-Duplex II	−2.8±0.2
A → 𝐴^𝑁	Single strand → ps-Triplex II	−3.3±0.2
	ps-Duplex II → ps-Triplex II	−0.5±0.2