BRCA1 Forms a Functional Complex with <svg     style="vertical-align:-4.698pt;width:11.35px;" id="M1" height="16.012501" version="1.1" viewBox="0 0 11.35 16.012501" width="11.35"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FE" d="M478 372q0 -39 -31 -97t-61 -98t-78 -98q-45 -55 -73 -102q-13 -79 -13 -197q-11 -11 -43.5 -25.5t-53.5 -15.5l-15 17q5 35 26 101.5t47 123.5q8 72 -1.5 174.5t-37.5 178.5q-14 37 -29 37q-20 0 -67 -65l-25 21q37 60 73 90.5t63 30.5q47 0 72 -112q13 -56 17.5 -141.5
t0.5 -143.5h2q155 193 155 297q0 26 -12 47q-5 8 -5 15q0 16 12.5 27t29.5 11q21 0 34 -21t13 -55z" /></g>

		
	
</svg>-H2AX as a Late Response to Genotoxic Stress

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="801594.fig.005a" src="https://static.hindawi.com/articles/jna/volume-2010/801594/figures/801594.fig.005a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>BRCA1: pRNApol II complex in undamaged cells</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="801594.fig.005b" src="https://static.hindawi.com/articles/jna/volume-2010/801594/figures/801594.fig.005b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Early repair complexes with <svg height="9.9375" id="M105" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.9375)">
<g transform="translate(72,-64.05)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛾</tspan>
</text>
</g>
</g>
</svg>-H2AX lack BRCA1</td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="801594.fig.005c" src="https://static.hindawi.com/articles/jna/volume-2010/801594/figures/801594.fig.005c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Late repair complexes with <svg height="9.9375" id="M106" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.9375)">
<g transform="translate(72,-64.05)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛾</tspan>
</text>
</g>
</g>
</svg>-H2AX and BRCA1</td></tr></table></td></tr></table>

<table>Model of BRCA1 interactions with RNA polymerase II and <svg height="9.9375" id="M104" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.9375)">
<g transform="translate(72,-64.05)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛾</tspan>
</text>
</g>
</g>
</svg>-H2AX in distinct biochemical complexes. See text for details.</table>

Journal of Nucleic Acids

fig5

Figure 5

Figure 5: BRCA1 Forms a Functional Complex with <svg     style="vertical-align:-4.698pt;width:11.35px;" id="M1" height="16.012501" version="1.1" viewBox="0 0 11.35 16.012501" width="11.35"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FE" d="M478 372q0 -39 -31 -97t-61 -98t-78 -98q-45 -55 -73 -102q-13 -79 -13 -197q-11 -11 -43.5 -25.5t-53.5 -15.5l-15 17q5 35 26 101.5t47 123.5q8 72 -1.5 174.5t-37.5 178.5q-14 37 -29 37q-20 0 -67 -65l-25 21q37 60 73 90.5t63 30.5q47 0 72 -112q13 -56 17.5 -141.5
t0.5 -143.5h2q155 193 155 297q0 26 -12 47q-5 8 -5 15q0 16 12.5 27t29.5 11q21 0 34 -21t13 -55z" /></g>

		
	
</svg>-H2AX as a Late Response to Genotoxic Stress 

Journal of Nucleic Acids

BRCA1 Forms a Functional Complex with -H2AX as a Late Response to Genotoxic Stress

Figure 5