The Roles of UmuD in Regulating Mutagenesis

Figure 2

The secondary and tertiary structure of UmuD₂ and UmuD^2. (a) Secondary structure comparison between the UmuD^2 NMR [44, 45] and crystal [46] structures. The 𝛼 helices are shown in red, and 𝛽 sheets are shown in blue. Relative deuterium incorporation of UmuD₂ at 30 sec labeling in HXMS experiments is shown, and the colors are based on the relative deuterium percentage scale shown [51]. (b) Comparison of the NMR [44, 45] and crystal [46] structures of UmuD^2. The color of the 𝛼 helices and 𝛽 sheets is consistent with (a). The active site regions are boxed and shown in the insets. A model of full-length UmuD₂ is shown [52].

(a)

(b)