Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases

Figure 3

Proposed function of secondary structure resolution by RecQ helicases. Alternate DNA structures (indicated by red symbol) act as natural barrier to replication fork progression and can lead to fork stalling, collapse and ensue recombinogenic processing. Resolution by RecQ helicases is proposed to serve as roadblock remover for smooth progression of replication fork to avoid mutagenesis and/or genome rearrangements.