About this Journal Submit a Manuscript Table of Contents
Journal of Nucleic Acids
Volume 2011 (2011), Article ID 870726, 5 pages
http://dx.doi.org/10.4061/2011/870726
Research Article

Distribution of 5-Hydroxymethylcytosine in Different Human Tissues

R&D Division, Epigentek Group Inc., 110 Bi County Boulevard, Suite 122, Farmingdale, NY 11735, USA

Received 5 January 2011; Revised 24 February 2011; Accepted 15 April 2011

Academic Editor: Dmitry Veprintsev

Copyright © 2011 Weiwei Li and Min Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. W. Laird and R. Jaenisch, “The role of DNA methylation in cancer genetics and epigenetics,” Annual Review of Genetics, vol. 30, pp. 441–464, 1996. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. W. Reik, W. Dean, and J. Walter, “Epigenetic reprogramming in mammalian development,” Science, vol. 293, no. 5532, pp. 1089–1093, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. K. D. Robertson, “DNA methylation and human disease,” Nature Reviews Genetics, vol. 6, no. 8, pp. 597–610, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. S. Kriaucionis and N. Heintz, “The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain,” Science, vol. 324, no. 5929, pp. 929–930, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. M. Tahiliani, K. P. Koh, Y. Shen et al., “Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1,” Science, vol. 324, no. 5929, pp. 930–935, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. M. Münzel, D. Globisch, T. Brückl et al., “Quantification of the sixth DNA base hydroxymethylcytosine in the brain,” Angewandte Chemie—International Edition, vol. 49, no. 31, pp. 5375–5377, 2010. View at Publisher · View at Google Scholar · View at PubMed
  7. G. R. Wyatt and S. S. Cohen, “A new pyrimidine base from bacteriophage nucleic acids,” Nature, vol. 170, no. 4338, pp. 1072–1073, 1952. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Valinluck, H. H. Tsai, D. K. Rogstad, A. Burdzy, A. Bird, and L. C. Sowers, “Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2),” Nucleic Acids Research, vol. 32, no. 14, pp. 4100–4108, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. D. Globisch, M. Münzel, M. Müller et al., “Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates,” PLoS ONE, vol. 5, no. 12, article e15367, 2010. View at Publisher · View at Google Scholar · View at PubMed
  10. A. Szwagierczak, S. Bultmann, C. S. Schmidt, F. Spada, and H. Leonhardt, “Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA,” Nucleic Acids Research, vol. 38, no. 19, p. e181, 2010. View at Publisher · View at Google Scholar · View at PubMed
  11. S. Ito, A. C. D'Alessio, O. V. Taranova, K. Hong, L. C. Sowers, and Y. Zhang, “Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification,” Nature, vol. 466, no. 7310, pp. 1129–1133, 2010. View at Publisher · View at Google Scholar · View at PubMed
  12. V. Valinluck and L. C. Sowers, “Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1,” Cancer Research, vol. 67, no. 3, pp. 946–950, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. F. Delhommeau, S. Dupont, V. Della Valle et al., “Mutation in TET2 in myeloid cancers,” The New England Journal of Medicine, vol. 360, no. 22, pp. 2289–2301, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. M. Ko, Y. Huang, A. M. Jankowska et al., “Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2,” Nature, vol. 468, no. 7325, pp. 839–843, 2010. View at Publisher · View at Google Scholar · View at PubMed
  15. S. V. Cannon, A. Cummings, and G. W. Teebor, “5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue,” Biochemical and Biophysical Research Communications, vol. 151, no. 3, pp. 1173–1179, 1988. View at Scopus