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Journal of Nucleic Acids
Volume 2011 (2011), Article ID 870726, 5 pages
Distribution of 5-Hydroxymethylcytosine in Different Human Tissues
R&D Division, Epigentek Group Inc., 110 Bi County Boulevard, Suite 122, Farmingdale, NY 11735, USA
Received 5 January 2011; Revised 24 February 2011; Accepted 15 April 2011
Academic Editor: Dmitry Veprintsev
Copyright © 2011 Weiwei Li and Min Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. W. Laird and R. Jaenisch, “The role of DNA methylation in cancer genetics and epigenetics,” Annual Review of Genetics, vol. 30, pp. 441–464, 1996.
- W. Reik, W. Dean, and J. Walter, “Epigenetic reprogramming in mammalian development,” Science, vol. 293, no. 5532, pp. 1089–1093, 2001.
- K. D. Robertson, “DNA methylation and human disease,” Nature Reviews Genetics, vol. 6, no. 8, pp. 597–610, 2005.
- S. Kriaucionis and N. Heintz, “The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain,” Science, vol. 324, no. 5929, pp. 929–930, 2009.
- M. Tahiliani, K. P. Koh, Y. Shen et al., “Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1,” Science, vol. 324, no. 5929, pp. 930–935, 2009.
- M. Münzel, D. Globisch, T. Brückl et al., “Quantification of the sixth DNA base hydroxymethylcytosine in the brain,” Angewandte Chemie—International Edition, vol. 49, no. 31, pp. 5375–5377, 2010.
- G. R. Wyatt and S. S. Cohen, “A new pyrimidine base from bacteriophage nucleic acids,” Nature, vol. 170, no. 4338, pp. 1072–1073, 1952.
- V. Valinluck, H. H. Tsai, D. K. Rogstad, A. Burdzy, A. Bird, and L. C. Sowers, “Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2),” Nucleic Acids Research, vol. 32, no. 14, pp. 4100–4108, 2004.
- D. Globisch, M. Münzel, M. Müller et al., “Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates,” PLoS ONE, vol. 5, no. 12, article e15367, 2010.
- A. Szwagierczak, S. Bultmann, C. S. Schmidt, F. Spada, and H. Leonhardt, “Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA,” Nucleic Acids Research, vol. 38, no. 19, p. e181, 2010.
- S. Ito, A. C. D'Alessio, O. V. Taranova, K. Hong, L. C. Sowers, and Y. Zhang, “Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification,” Nature, vol. 466, no. 7310, pp. 1129–1133, 2010.
- V. Valinluck and L. C. Sowers, “Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1,” Cancer Research, vol. 67, no. 3, pp. 946–950, 2007.
- F. Delhommeau, S. Dupont, V. Della Valle et al., “Mutation in TET2 in myeloid cancers,” The New England Journal of Medicine, vol. 360, no. 22, pp. 2289–2301, 2009.
- M. Ko, Y. Huang, A. M. Jankowska et al., “Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2,” Nature, vol. 468, no. 7325, pp. 839–843, 2010.
- S. V. Cannon, A. Cummings, and G. W. Teebor, “5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue,” Biochemical and Biophysical Research Communications, vol. 151, no. 3, pp. 1173–1179, 1988.