Cell-Specific Aptamers as Emerging Therapeutics

Table 3

Aptamers for cell-specific delivery of drug molecules.

Target molecule	Aptamer	Drug molecules linked or complexed with the aptamer	Lit.
PSMA	2′-F-modified RNA	(1) siRNAs/shRNAs	(1) [88–92]
		(2) Protein toxin gelonin	(2) [93]
		(3) Dox	(3) [94]
		(4) QDs, SPION or gold NPs with Dox	(4) [95–99]
		(5) Pt(IV)-encapsulated PLGA-PEG NPs	(5) [100]
gp120	2′-F-modified RNA	siRNAs	[101, 102]
Nucleolin	DNA	PDT agent TMPyP4	[103]
PTK7	DNA	Dox	[104]
TfR	DNA	L-iduronidase	[105]
MUC1	DNA	PDT agent chlorin 𝑒6	[106]
EGFR	RNA	Gold NPs	[107]
IgM heavy chain	DNA	Micelle-like nanostructures	[108]