Research Article

Identification of Genes Regulating Gene Targeting by a High-Throughput Screening Approach

Table 1

Validation of the candidate genes. Candidate genes were selected after secondary screening. siRNAs targeting various mRNA sequences were tested for their ability to stimulate homologous gene targeting. Results are the means of at least 3 independent experiments.

siRNA targetMean stimulation factorStd value

ATF7IP3.61.0<.05
EP3003.00.9<.05
SERPINB22.51.1<.05
NDUFV12.20.6<.05
LRDD2.00.6<.05
ATR2.00.7<.05
POP71.80.6<.05
FLJ356951.80.2<.05
DCDC21.60.6<.05
RBP11.50.2<.05
LIFR1.50.6<.05
EFEMP21.40.2<.05
USP201.40.73>.05
TRIM31.40.67>.05
TOP11.30.5>.05
HUWE11.30.3>.05
SPRED31.30.6>.05
C9orf851.20.8>.05
LRRC161.10.58>.05
CCDC461.00.3>.05
KIF70.90.4>.05