Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Figure 3
Hydration pattern within the LNA duplex (PDB ID: 2X2): a region of the LNA helix showing the base pair (G4-m5C69)L. The hydration pattern resembles that known for RNA, as the bridged 2′-oxygen atom in LNA acts as a hydrogen bond acceptor similar to the 2′-oxygen in the hydroxyl group of RNA.
