Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

Figure 6

Overall helical structures of natural nucleic acids (RNA and DNA) and of synthetic, modified nucleic acids (LNA, GNA, and PNA). All helices were extended to a total of 46 base pairs. The helices were constructed by using the following structures: DNA (idealized), RNA (idealized), LNA (PDB ID: 2X2Y), GNA (PDB ID: 2JJA), and PNA (PDB ID: 1PUP). Phosphate oxygen atoms are shown in blue, phosphates in yellow, and all other atoms are presented in grey. Top picture shows the side view of the duplexes and the bottom picture presents a projection along the helical axis.