Research Article
Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Table 1
Data and refinement statistics of
microhelix and LNA helix [
9,
15].
| | tRNASer microhelix | LNA helix |
| | Data acquisition | | | | Space group | C2 | C2 | | Cell constants | | | | a, b, c (Å) | 35, 79, 39.13, 31.37 | 77.91, 40.74, 30.06 | | α, β, γ (°) | 90.00, 111.1, 90.00 | 90.00, 91.02, 90.00 | | Resolution (Å) | 120–1.20 (1.22–1.20) | 80.00–1.90 (1.93–1.90) | | 7.4 (15.4) | 7.3 (21.7) | | I/σI | 18.7 (1.8) | 19.7 (1.0) | | Completeness (%) | 99.2 (99.1) | 98.0 (97.2) | | Redundancy | 7.1 (8.6) | 4.8 (3.8) |
| | Refinement | | | | No. of reflections | 12,806 | 7,382 | | / | 19.0 (20.1) | 22.9 (28.8) | | Atoms | | | | Nucleic acid | 293 | 314 | | Magnesium | 2 | 1 | | Cobalt hexamine | — | 3 | | Water oxygens | 97 (2 mol/au) | 44 |
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Values in parentheses are given for the highest-resolution shell.
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